1 Most clinical series show that 60%–80% of patients are women of childbearing age 2, –, 4 who sometimes develop the encephalitis during pregnancy. Glossary BBB = blood-brain barrier CBA = cell-based assay fEPSP = field excitatory postsynaptic potential GEE = generalized estimated equation GLM = generalized linear model IgG = immunoglobulin G LTP = long-term potentiation NMDAR = NMDA receptor NMDAR-ab = NMDAR antibody NOL = novel object location PD = postnatal day PPI = prepulse inhibition PSD95 = postsynaptic density protein 95Īnti-NMDA receptor (NMDAR) encephalitis is a neuronal antibody-mediated disease that associates with prominent neurologic and psychiatric symptoms.

From the Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) (A.G.-S., M.R., A.P., V.B., E.A., E.M., H.A., M.S., F.M., M.P., B.J., S.G., J.P., J.D.), Hospital Clínic, Universitat de Barcelona Departament de Biomedicina (A.P., V.B., S.G.), Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) (A.P., V.B., S.G.), Madrid Medical Statistics Core Facility (J.R.), IDIBAPS and Hospital Clínic, Barcelona Biostatistics Unit (J.R.), School of Medicine, Universitat Autònoma de Barcelona Centro de Investigaciones Biomédicas en Red de Enfermedades Raras (CIBERER) (J.D.), Madrid, Spain Department of Neurology (J.D.), University of Pennsylvania, Philadelphia and Institució Catalana de Recerca i Estudis Avançats (ICREA) (J.D.), Barcelona, Spain.

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